The Asthma Phenotype in the Obese: Distinct or Otherwise?

HIGHLIGHTED TOPIC Pulmonary Physiology and Pathophysiology of Obesity Does obesity produce a distinct asthma phenotype?

Lugogo NL, Kraft M, Dixon AE. Does obesity produce a distinct asthma phenotype? J Appl Physiol 108: 729–734, 2010. First published October 29, 2009; doi:10.1152/japplphysiol.00845.2009.—Obesity and asthma prevalence have been increasing over the past decade. Epidemiological evidence demonstrates that obesity results in an increased risk of developing incident asthma. Even modest levels of incre...

[Bronchial asthma in obesity--a distinct phenotype of asthma?].

Asthma and obesity have a considerable impact on public health and their prevalence has increased in recent years. Numerous large cross-sectional and prospective studies performed in adults, adolescents, and children throughout the world supports the hypothesis that obesity is an independent risk factor for asthma. The pathogenetic basis for asthma and obesity associations in humans is not w...

Role of Obesity in Asthma Control, the Obesity-Asthma Phenotype

Asthma is a disease with distinct phenotypes that have implications for both prognosis and therapy. Epidemiologic studies have demonstrated an association between asthma and obesity. Further studies have shown that obese asthmatics have poor asthma control and more severe asthma. This obese-asthma group may represent a unique phenotype. The mechanisms behind poor asthma control in obese subject...

In Search of the Best Candidate for Detection of Metabolically Obese Normal-Weight Phenotype

Airway Inflammatory Biomarker: Could It Tailor the Right Medications for the Right Asthmatic Patient?

Asthma is a heterogeneous disease, in which asthmatic patients present with different clinical phenotypes, variable endotypes, and different response to asthma medicines. Thus, we are faced with an asthma paradox; asthma is diagnosed subjectively by clinical history and treated with biologically active drugs. To solve this paradox, we need objective airway biomarkers to tailor the proper medica...